P3 SURGERY
During oral, endodontic, implant, bone grafting and periodontal surgeries, it is important to create a biologically friendly environment to encourage bone regeneration.
Physiological pH: Diseased dental surgical sites have an acidic pH which inhibits the osteogenic process of bone regeneration. P3 formulations are buffered to a neutral pH 7.0 thus creating an environment conducive to bone regeneration.
Anticollagenase: The first step in bone regeneration is the formation of a collagen matrix which is subsequently mineralized to form mature bone. In a diseased dental surgical site, the high concentration of collagenase rapidly breaks down the newly formed collagen produced by fibroblasts. P3 formulations are a potent neutralizer of the harmful enzyme collagenase.
Microbial Specificity: The active ingredient (doxycycline) in P3 Surgery targets the pathogenic bacteria found in diseased dental surgical sites.
Calcium Supersaturation: In order to drive the osteogenic/osteoclastic equilibrium in the direction of osteogenesis, there must be a readily available source of calcium in the surgical field. P3 formulas are supersaturated with calcium.
Substantivity: Because the active ingredient in P3 has the ability to reversibly bind (not irreversibly bond) to alveolar bone and root surfaces, it is slowly released over an extended period to facilitate the normal physiological process of bone regeneration.
Proper Concentration: There is an exact concentration of active ingredient that must be present to achieve the desired clinical results. During surgery it is possible there will be a dilution of P3 by blood or irrigation. P3 Surgery has a higher concentration of active ingredient to allow for this possible dilution.
Summary: When atraumatic microsurgical techniques are employed at tissue level and followed by application of P3 at the cellular molecular levels, the stage is set for a successful surgical result, including regeneration of alveolar bone.